Hotels & Motels in Santee SC

Find your home away from home in Santee Cooper County, South Carolina whether you want to be steps from the lake or conveniently near I-95—pretty much the same in our case! We have a number of excellent hotels from tried-and-true favorites like Holiday Inn and Best Western Plus to local favorites like Historic Clark’s Inn, dating back to 1946. No matter what suits you and your party best, you’ll find it here. Book your stay today!

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What our Visitors Say

“Large, clean! modern rooms with many USB ports and outlets. Lots of space to walk your dog. Pleasant, friendly staff throughout. Nice doggie gift bag upon check in, and staff helpfully provided a list of local restaurants. Hotel is right off 95 but far enough away that noise from the highway isn’t noticeable.”
Kari Reed
Google Reviews - Hampton Inn Santee I95